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FOSAMAX PLUS D

May 11th, 2008

Merck & Co, Inc. Declared today that USA Food and Administration Medicine has approved FOSAMAX PLUS DTM

(alendronate natriy/cholecalciferol), single as only-weekly tablet, containing 70 mg. FOSAMAX (alendronate sodium) and 2800 vitamins IU D3, presenting 7 days worth of 400 IU vitamin D. ( recommended admission of the vitamin D - 400-800 IU daily). FOSAMAX is DEMONSTRATED to reduce the risk both hip and spine conks in postmenopausal woman with osteoporosis and - now single bisphosphonate with additional advantage over weekly dose of the vitamin D.

FOSAMAX - single bisphosphonate that is specified to vastly reduce the risk both osteoporotic hip and fracture of the spine. Firm efficiency FOSAMAX for processing osteoporosis in postmenopausal woman was demonstrated in test, which came to light in over 10 years therapy FOSAMAX 10 mg. as soon as daily maintained or continued to help to build the bone.

About osteoporosis

Osteoporosis Can conduct to bone loss and increased risk fracture. Osteoporosis Particularly general in woman after menopause but also occurs in man. Most often, this is due to increase in factor resorption (the breakages) bone fabrics that did not correspond to the factor of the bone formation.

Important information on FOSAMAX and FOSAMAX PLUS D(R) (alendronate/cholecalciferol)

The Patients must talk with their doctor if they have or had a problems with swallowing. Besides, patients must talk with their doctor if they have a condition, which can cause the over-production of the vitamin D (eg., sarcoidosis, leukemia, lymphoma). The Patients must report their doctor on all medicine, which they take, including prescription and not-medicine of the prescription, vitamins and herbal additions.

Some patients can develop the serious digestive reactions including irritation, inflammation or forming the canker of the gullet. The Risk serious esophageal experience turns out to be will be big on patient, which do not follow dosing instruction (see to assign to information for more details). The Patients, which feel new or worsenning heartburn, difficulty or pain at swallowing or chest pain must cease to take the medicine and name their doctor immediately. The Patients, which develop the serious bone, joint and/or pain of the muscle anytime must address to their doctor. Most general registered side effects with FOSAMAX in clinical study were an abdominal pain (3.7 percent), musculoskeletal pain (2.9 percent), indigestion (2.7 percent), (1.9 percent) and sickness (1.9 percent).

Standard dosing mode for FOSAMAX and FOSAMAX PLUS D(R), includes swallowing tablet with six times in eight ounces of the plain to water the first thing on appearing for day and at least once 30 minutes before the first food, drink or medication of the day. After swallowing FOSAMAX or FOSAMAX PLUS D, patients must not lie for at least once 30 minutes downwards and not until after absorb their first food of the day. The Patients must not chew or be suckled in tablet FOSAMAX or FOSAMAX PLUS D.

” Approval FOSAMAX PLUS D - an important news to womans diagnosed osteoporosis,” said Dr. Professor Robert Heaney, Medicine, University Creighton. “This product will provide the important new option, providing well documented clinical advantage over FOSAMAX with additional advantage that that patients, sending this gets the weekly dose of the vitamin D. Have a product like FOSAMAX PLUS D available to help the physician better to control feeding the vitamin D on their patient must be welcomed news to supposed 10 million American, which have osteoporosis and physicians, which process them.”

Supporting required level of the vitamin D required for development strong bones since he helps increase to absorption intestinal calcium. Insufficiency of the Vitamin D is bound shortened by calcium absorption, bone loss, and increased risk of the fracture. The Patients in raised risk for insufficiency of the vitamin D (eg. that, which nurses-house bound, chronically ill, age 70 years) and with gastrointestinal malabsorption syndrome must get the addition of the vitamin D in addition to which provided in FOSAMAX PLUS D.

FOSAMAX PLUS D provides the proved power FOSAMAX, worldwide givenned osteoporosis processing, what is demonstrated to vastly reduce the risk both osteoporotic hip and fracture of the spine. Firm efficiency FOSAMAX for processing osteoporosis in postmenopausal woman was demonstrated in test, which came to light in over 10 years therapy FOSAMAX 10 mg. as soon as daily maintained or continued to form the bone.

FOSAMAX PLUS D is specified for processing osteoporosis in postmenopausal woman. For processing osteoporosis, FOSAMAX PLUS bone increase D to massage and reduces incidence of the fracture, including that hip and spine. FOSAMAX PLUS D is also specified to enlarge the bone mass in man with osteoporosis.

FOSAMAX PLUS D, like the other bisphosphonate products, must be used by warning on folk with determined belly or digestive problem. FOSAMAX PLUS D must is not used if patient has determined disturbances of the gullet, which delays emptying or if patient - unable to install or sit the for at least once 30 minutes. Besides, FOSAMAX PLUS D must is not used on patient with serious kidney disease or low level calcium on their shelters, on patient, which allergic on FOSAMAX PLUS D or on patient, which - pregnant or feeding. FOSAMAX PLUS D only must is not used to process the defect of the vitamin D.

The Price of the directory FOSAMAX PLUS D will be an equivalent to price mg. tablet FOSAMAX 70.

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